chiro-Inositol Derivatives from Chisocheton paniculatus Showing Inhibition of Nitric Oxide Production
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- Khan Viet Nguyen, Duc Viet Ho, Hien Minh Nguyen, Thao Thi Do, Kiem Van Phan, Hiroyuki Morita, Jyrki Heinämäki, Ain Raal*, and Hoai Thi Nguyen*
Cite this: J. Nat. Prod. 2020, 83, 4, 1201–1206
Publication Date:March 25, 2020
Copyright © 2020 American Chemical Society and American Society of Pharmacognosy
Six new chiro-inositol derivatives (1–6) were isolated from the leaves of Chisocheton paniculatus collected in Vietnam. Their chemical structures were elucidated by 1D and 2D NMR and HRESIMS analyses. All isolated compounds were evaluated for their inhibitory activity against lipopolysaccharide-induced nitric oxide (NO) production in the RAW 264.7 macrophage cell line. Compound 4 exhibited potent inhibitory activity for NO production with an IC50 value of 7.1 μM.