Phytochemical Constituents of Annona reticulata and their Cytotoxic Activity
- Lượt xem: 2340
Ty Viet Pham, Thang Quoc Le, Anh Tuan Le, Hung Quoc Vo, Duc Viet Ho*
Journal Name: Letters in Organic Chemistry
Volume 17 , Issue 3 , 2020
A phytochemical investigation of the leaves of Annona reticulata led to the isolation and structural determination of β-sitosterol (1), ent-pimara-8(14),15-dien-19-oic acid (2), ent-pimara- 8(14),15-dien-19-ol (3), quercetin (4), quercetin 3-O-α-L-arabinopyranoside (5), and a mixture of quercetin 3-O-β-D-galactopyranoside (6a) and quercetin 3-O-β-D-glucopyranoside (6b). Of these, compounds 2 and 3 were isolated from the genus Annona for the first time. Compound 3 showed strong cytotoxicity against SK-LU-1 and SW626 cell lines with IC50 values of 17.64 ± 1.07 and 19.79 ± 1.41 μg mL-1, respectively.
Keywords: Annona reticulata, Annonaceae, pimarane-type diterpene, flavonoid, cytotoxicity, SK-LU-1, SW626