Ty Viet PhamThang Quoc LeAnh Tuan LeHung Quoc VoDuc Viet Ho*

 

Journal Name: Letters in Organic Chemistry

Volume 17 , Issue 3 , 2020

DOI : 10.2174/1570178616666190724123004

 

 

Graphical Abstract:

Abstract:

A phytochemical investigation of the leaves of Annona reticulata led to the isolation and structural determination of β-sitosterol (1), ent-pimara-8(14),15-dien-19-oic acid (2), ent-pimara- 8(14),15-dien-19-ol (3), quercetin (4), quercetin 3-O-α-L-arabinopyranoside (5), and a mixture of quercetin 3-O-β-D-galactopyranoside (6a) and quercetin 3-O-β-D-glucopyranoside (6b). Of these, compounds 2 and 3 were isolated from the genus Annona for the first time. Compound 3 showed strong cytotoxicity against SK-LU-1 and SW626 cell lines with IC50 values of 17.64 ± 1.07 and 19.79 ± 1.41 μg mL-1, respectively.

Keywords: Annona reticulata, Annonaceae, pimarane-type diterpene, flavonoid, cytotoxicity, SK-LU-1, SW626